The AudioNotch Tinnitus Treatment Blog

Vagal Nerve Therapy Trial Recruiting Patients

An American clinical trial is being launched for Vagal Nerve Therapy for tinnitus. This is pretty exciting news (although the research thus far is limited). A summary below:

The new study uses a technique known as vagus nerve stimulation (VNS) that takes advantage of the brain’s ability to reconfigure itself (neuroplasticity). During the therapy, patients wear headphones and hear a series of single frequency tones, paired with stimulation to the vagus nerve, a large nerve that runs from the head and neck to the abdomen. When stimulated, the vagus nerve releases acetylcholine, norepinephrine, and other chemicals that encourage neuroplasticity.

In an earlier NIDCD-funded study using a rat model, the technique was shown to reorganize neurons to respond to their original frequencies, subdue their activity, and reduce their synchronous firing, suggesting that the ringing sensation had stopped. The scientists subsequently tested a prototype device in a small group of human volunteers in Europe and observed encouraging results.

For this new study, two groups of adults who have had moderate-to-severe tinnitus for at least one year will participate in daily 2.5 hour sessions of VNS and audio tone therapy over six weeks. One group will get the VNS and tone test treatment immediately; the other will get a combination of VNS and tones that is not expected to have a therapeutic benefit. After six weeks, both groups will receive active test treatment.

13 Responses to “Vagal Nerve Therapy Trial Recruiting Patients”

  1. Sam Goklani said:

    Apr 20, 14 at 9:24 am

    Am willing to volunteer for vagal nerve stimulatin trials

  2. Sam Goklani said:

    Apr 20, 14 at 9:26 am

    Am willing to volunteer for vagal nerve stimulation trials

  3. Peter Spinelli said:

    Apr 20, 14 at 1:11 pm

    Would love to be considered as a participant in the new VNS study….if that can be accomplished here in the Birmingham, AL area. I have had a relatively serious bout with Tinitus for many years and it increased in intensity (and changed it’s perceived location in my head) after a near-fatal helicopter crash in 2006. Please let me know who I must contact to attempt make that happen, OK ?

    Thanks !

  4. Peter said:

    May 07, 14 at 7:23 am

    Sorry Pete, we’re not the group running the study.

  5. Robert Hillman said:

    Apr 20, 14 at 4:10 pm

    I live in Chicago and would love to be considered for this study. I head up a suburban tinnitus support group and we have discussed vagal nerve therapy a lot. I would like to be able to participate, not only to see if it helps the severe tinnitus which I have had for many years, but to be able to report back to my group on what I experienced. If you have any room, whatsoever, please include me. I continue to do all I can to help people who suffer from tinnitus. It is my mission in life. This therapy would be a big step forward, especially if I can give my group members hope. Thank you.

  6. Gareth Gravell said:

    Apr 21, 14 at 12:30 am

    Should you require any more volunteers to test this vagal nerve therapy, i would be happy to take part.

  7. Peter said:

    May 07, 14 at 7:22 am

    We’re not the ones running the study, I was just posting news about it.

  8. Benjie Caneda, Jr. said:

    Apr 21, 14 at 12:46 am

    Is there any natural method of curing tinnitus. The blog is more on synthetic drugs which only benefits the pharma companies. If this blog, site or group is intended for the patients with Tinnitus, why not share the natural method (vegies, exercise, etc.).



  9. Peter said:

    May 07, 14 at 7:22 am

    That’s because there are no natural cures for tinnitus. They’re pure pseudoscience:

  10. Tony carter smith said:

    Apr 21, 14 at 3:29 am

    I hope it works I would happily be a guinea pig

  11. Ronald Valentine said:

    Apr 21, 14 at 3:31 am

    I suffer with tinnitus and would like to participate in the US trials.

  12. Yaron Gudes said:

    Apr 29, 14 at 6:14 pm

    I am also interested to participate in this study should volunteers be needed. 

  13. Peter said:

    May 07, 14 at 7:20 am

    I don’t know anything about recruitment for this in terms of the details, unfortunately.

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